Medical therapy

Estimated benefit of combined medical therapy in heart failure with mildly reduced and preserved ejection fraction

Disclosures Dr. Vaduganathan has received research grants or served on advisory boards for American Regent, Amgen, AstraZeneca, Bayer AG, Baxter Healthcare, Boehringer Ingelheim, Cytokinetics, Lexicon Pharmaceuticals, Novartis, Pharmacosmos, Relypsa, Roche Diagnostics, and Sanofi; has had speaking engagements with Novartis and Roche Diagnostics; and participates in clinical trial committees for studies sponsored by Galmed, Novartis, Bayer AG, Occlutech and Impulse Dynamics. Dr. Claggett reports consulting fees from Amgen Inc, Beren Therapeutics, Myokardia, Novartis and Peerbridge Health. Dr. Fonarow reports receiving research funding from the National Institutes of Health and consulting for Abbott, Amgen, AstraZeneca, Bayer, Cytokinetics, Edwards, Medtronic, Merck, and Novartis. Dr McMurray has received payments to his employer, University of Glasgow, for his work on clinical trials, consultancy and other activities from Alnylam, Amgen, AstraZeneca, Bayer, BMS, Cardurion, Cytokinetics, GSK, Novartis, Pfizer and Theracos, as well as personal conference fees from Corpus, Abbott, Hickma, Sun Pharmaceuticals and Medsca. Dr. Solomon has received research grants from Actelion, Alnylam, Amgen, AstraZeneca, Bellerophon, Bayer, BMS, Celladon, Cytokinetics, Eidos, Gilead, GSK, Ionis, Lilly, Mesoblast, MyoKardia, National Institutes of Health/National Heart , Lung, and Blood Institute, Neurotronik, Novartis, NovoNordisk, Respicardia, Sanofi Pasteur, Theracos and US2.AI; Dr. Solomon consulted Abbott, Action, Akros, Alnylam, Amgen, Arena, AstraZeneca, Bayer, Boehringer-Ingelheim, BMS, Cardior, Cardurion, Corvia, Cytokinetics, Daiichi-Sankyo, GSK, Lilly, Merck, Myokardia, Novartis, Roche , Theracos, Quantum Genomics, Cardurion, Janssen, Cardiac Dimensions, Tenaya, Sanofi-Pasteur, Dinaqor, Tremeau, CellProThera, Moderna, American Regent and Sarepta. Dr. Inciardi reports no conflicts.